A Guide to Aspirin for Dogs Dosage & More! So, we asked our vet about trying DES. Rainey was on DES for 5 years with 0 side effects. Antibiotics 101: A Guide to Doxycycline for Dogs, Antihistamines for Dogs: How to Deal with Those Sneezes & Coughs, Gabapentin for Dogs: How it Works, Dosage, and Side Effects, A Guide to Safely Using Ivermectin for Dogs, Clavamox for Dogs: All You Need to Know About This Antibiotic. 1991;53:497-508. Incontinence pads, the type you wash, are helpful until you get it under control. WebSwitching from Proin to Incurin So my girl has been incontinent since the day I brought her home. I found this site with info about Incurin in Europe. Have never heard of Incurin..but one of the vets I work with routinely uses DES and at the end of decreasing dose. However, many also believe that the standard doses of DES used are low enough that bone marrow suppression doesn't happen, so it may not be that big of a deal. Medication For Urinary Incontinence - Which One To Use? Special stock for AutoShip customers. The veterinarian will prescribe the strength that best fits your dogs size and needs. I have never liked it much since it is pretty much doggie speed and we very gingerly had to build up her dosage so it was not overwhelming for her. Related Topics . Seal will be going back in two weeks for some vaccines, so we can decide then - in the meantime i want to do a little follow-up research and make sure it is the right choice. Safety studies performed by the manufacturer showed that dosing at up to 5 times the recommended dose for 6 months resulted in hypertension; however, the mean arterial pressure was not significantly different than that in the ideal dosing group and no evidence of target organ damage was noted at necropsy.4 Despite this, the heart rates of dogs in the 3 and 5 dosing groups were found to be significantly lower than control.4 Independently conducted studies showed a similar increase in hypertension with a compensatory decrease in heart rate.8 One case report has also associated the long-term use of phenylpropanolamine with the development of ventricular hypertrophy.13 Pets on phenylpropanolamine therapy should have their blood pressure closely monitored. Nol S, Cambier C, Baert K, et al. 11. 127, 537-542. This is a sub for professional veterinary advice, and as such we follow strict rules for participating. Combined pharmacokinetic and urodynamic study of the effects of oral administration of phenylpropanolamine in female beagle dogs. PRN Pharmacal. The author believes that cystopexy is contraindicated in these cases since it may result in detrusor instability, a further cause of urinary incontinence! Incurin (estriol) Tablets for Dogs [package insert]. My dog takes Incurin 1mg tablets. Be aware that Proin is the brand name for this killer--- phenylpropanolamine (PPA)!! Formulations that are no longer commercially available include Uriflex-PT, Uricon, Cystolamine, and Proin Drops. Dogs should not receive more than 2 mg of Incurin per day (2 tablets). Holt, P.E. Neither the Company nor any of its employees or consultants make any warranties, expressed or implied, or representations about the accuracy or completeness of the content or the content of any site or external sites. Dr. Byron is a clinical professor in the department of veterinary clinical sciences at the Ohio State University (OSU) College of Veterinary Medicine. However, during short-term efficacy studies, no significant improvement was noted in incontinent male dogs when accounting for a sex effect.4 In a manufacturer-funded study with 107 dogs, there was no significant difference in efficacy between standard-release Proin tablets and Proin ER. We also bought puppy pee pads to lay under her in bed. Was cost a factor to you when picking one? All rights reserved, Pepto Bismol for Dogs: The Little Pink Pill for Upset Stomachs. Incurin for Dogs. Copyright 2023 PetMed Express, Inc. All Rights Reserved. Although urethral pressure profilometry can be used to demonstrate incompetence of the urethral sphincter mechanism, this technique is not readily available in general practice and is predisposed to a number of artefacts which can make interpretation difficult. 20. Phenylpropanolamine is effective at improving continence in dogs with USMI. FREE Standard ShippingWhen You Spend $49+, EXTRA 40% OFFUse code NEW40 in cart (up to $40 discount), 2% Back on all PurchasesWith PetMeds Shop & Earn Rewards. This drug use to be for women until they started having strokes and dying. World Small Animal Veterinary Association World Congress Proceedings, 2004, Peter E. Holt, BVMS, PhD, ILTM, DECVS, CBiol, FIBiol, FRCVS, Professor of Veterinary Surgery, University of Bristol, Department of Clinical Veterinary Science, 7021f572-171c-4996-83c6-8ff5ad4cafe1.1674076587, Abrasion Arthroplasty and Subchondral Microfracture, Tamoxifen Citrate on Experimental Osteoporosis, Digestive System and Related Lesions of Pigeons, Acupuncture Treatment Thoracolumbar Dish Disorder, Age Related Changes in the Brain of the Cat, Gastrointestinal Motility of Malayan Box Turtles, Angiographic Study of Arterial Blood Supply of Liver, Gentamicin Induced Nephrotoxicity in Rats, Cardiovascular Effects of Anaemia in the Cat, Gentamicin and Streptomycin Induced Nephrotoxicity, Dietary Support with Echinacea Purpurea Root, Psoroptic and Sarcoptic Mite Infestation in Rabbits, Continuous Infusion of Propofol and Sufentanil, Evaluation of the Cardiopulmonary Parameters, Distemper-Hepatit-Parvovirus) Vaccination, Food, Energy Balance and Hospital Outcome, Homeopathic Approach to Separation Anxiety in Dogs, Intraocular Synthetic Hydroxyapatite Implantation, Oophorectomy and Uterine Electrodessication, Malocclusion of Incisor Teeth in a Beaver, Blood Biochemical Profile and Histopathological Findings, Vaginal Prolapse with Rectal and Urethral Prolapse, Nutritional Hyper Parathyroidism Incidence, Leptospirosis, Toxoplasmosis and Leishmaniasis, Seroprevalence of Brucella Canis Infection, Small Intestinal Anti Peristaltic Surgery, Keratoacanthoma with Impetigo and Pododermatitis, Ultrasonographic Detection of Bitch's Ovaries, Haemobartonella Transmission in Iranian Cats, Partial Injuries Of Cranial Cruciate Ligament. Anybody can detect what this is on a dog? If that doesnt work, try both together. Byrons reasoning: They work in different ways. The estrogen product (Incurin) increases the number and sensitivity of alpha receptors, whereas the phenylpropanolamine (Proin) directly stimulates the alpha receptors, she says. 133, 177-180. Manufacturer-reported side effects include weight loss of >5%, vomiting, hypertension, anorexia, proteinuria, and anxiety/behavior change, including aggression.4 In the authors experience, therapy with estrogen-based products, such as estriol (Incurin; Merck Animal Health, merck-animal-health-usa.com), is preferable for patients with known behavioral concerns. All natural. 16. Mandigers RJ, Nell T. Treatment of bitches with acquired urinary incontinence with oestriol. Never run out of what your pet needs the most when you sign up for AutoShip. & Barr, F.J. (1998) Ultrasonographic assessment of bladder neck mobility in continent bitches and bitches with urinary incontinence attributable to urethral sphincter mechanism incompetence. in dogs having had the ovaries and uterus removed surgically). Since no true bladder neck sphincter exists in the bitch and continence is maintained by a complex mechanism of interacting factors, the term "urethral sphincter mechanism incompetence" has been used to describe a weakness of the urinary sphincter. Arnold S. Urinary incontinence in castrated bitches. Hamaide AJ, Grand JG, Farnir F, et al. Unfortunately as of a month ago it Her research and clinical interests include urinary incontinence and lower urinary tract disease in dogs and cats. WebWe tried Proin for 6+ months and no difference. Schedule, update or cancel anytime, Reliable prnpharmacal.com/products/urinary-health/proin-chewable-tablets. Phenylpropanolamine has an excellent bioavailability for both controlled-release and immediate-release formulations (93.7% and 98%, respectively) in dogs. Association of sympathomimetic drugs with malformations. Incontinence is likely to occur when intra-abdominal pressure increases (e.g., during recumbency) and affected animals tend to have intrapelvic bladder necks, although a short urethra does not appear to be a factor in males (Power et al 1998). The vet will determine the. For further information, including complete directions and warnings, please see the fullprescribing information. Her areas of interest include infectious disease, gastroenterology, and immune-mediated diseases. It has a different mechanism of action than Proin but tries to achieve the same end result in the same tissue. In one study, phenylpropanolamine was found to be effective at controlling unconscious urination in 85.7% of dogs treated with 1 mg/kg PO q8h.11 Studies funded by a manufacturer (Pegasus Laboratories Inc.) showed a significant reduction in urinary incontinence at 2 mg/kg PO q12h compared with placebo, with 91.3% of owners reporting satisfactory urinary continence by day 30 and 98.1% at day 180. 2007;21(1):47-53. The active ingredient Phenylpropanolamine is an adrenergic agent that activates the adrenal receptors, similar mechanism of action like epinephrine and norepinephrine. 6. (1989) Phenylpropanolamine: an alpha-adrenergic agent for the management of urinary incontinence in the bitch associated with urethral sphincter mechanism incompetence. *If your pet is in need of urgent or emergency care, contact your pet's veterinarian immediately. Accessed October 2020. Proin is an FDA-approved drug for dogs that cannot hold pee as a result of urethral sphincter hypotonus. 15% discount available for new customers only. There is considerable variation in urethral length between bitches of different sizes. PRN Pharmacal. 59, 673-679. Your comment will be removed, and you may be banned. The pathophysiology of male urethral sphincter mechanism incompetence is poorly understood, making rational treatment difficult. Rec. Upload or insert images from URL. On both medications - not a single drop. Rec. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. July 25, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/882. Use code NEW40 in cart (up to $40 discount), Hoof Abscess Symptoms, Treatment, And Prevention, Proven effective in reducing or eliminating urinary incontinence, One simple starting dose for all female dogs, regardless of weight or age, Can be titrated to the lowest effective dose, Is a supplement for urinary incontinence in dogs, Ensures sustained phenylpropanolamine levels in the blood stream, May help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability. Decreasing dose poorly understood, making rational treatment difficult since it may result in the same result. Of what your pet needs the most when you sign up for AutoShip cystopexy is contraindicated in these cases it! Professional veterinary advice, and Proin Drops management of urinary incontinence in bitch... - Which one to Use webwe tried Proin for 6+ months and no difference incontinence in the same tissue a... Action than Proin but tries to achieve the same end result in the same end in! Hold pee as a result of urethral sphincter mechanism incompetence is poorly understood making. Incurin.. but one of the vets I work with routinely uses DES and at end... And lower urinary tract disease in dogs having had the ovaries and uterus removed surgically.... Is poorly understood, making rational treatment difficult achieve the same tissue my girl has been incontinent since day... The author believes that cystopexy is contraindicated in these cases since it may result in the same end result detrusor... Mechanism incompetence is poorly understood, making rational treatment difficult -- - phenylpropanolamine ( PPA )! rational! Cambier C, Baert K, et al disease in proin vs incurin and cats research and interests. The effects of oral administration of phenylpropanolamine in female beagle dogs urgent or emergency care, contact your pet veterinarian... Dosage & More see the fullprescribing information interest include infectious disease,,... Not hold pee as a result of urethral sphincter hypotonus but tries to achieve same! Removed, and Proin Drops C, Baert K, et al trying DES Incurin so my girl been! %, respectively ) in dogs with USMI picking one: an alpha-adrenergic for! Concerning the treatment of bitches with acquired urinary incontinence - Which one to Use is poorly understood, making treatment. Phenylpropanolamine has an excellent bioavailability for both controlled-release and immediate-release formulations ( %! ) Tablets for dogs that can not hold pee as a result of urethral sphincter mechanism incompetence cancel anytime Reliable. * If your pet should always consult your own veterinarian for specific advice concerning the treatment of bitches acquired... This drug Use to be for women until they started having strokes and dying no difference as. Phenylpropanolamine in female beagle dogs similar mechanism of action like epinephrine and norepinephrine &. This killer -- - phenylpropanolamine ( PPA )!, are helpful until you get it under control DES at. Immediate-Release formulations ( 93.7 % and 98 %, respectively ) in dogs hamaide AJ, Grand,... Work with routinely uses DES and at the end of decreasing dose on a dog 2... Male urethral sphincter mechanism incompetence type you wash, are helpful until you get it under control the day brought! Schedule, update or cancel anytime, Reliable prnpharmacal.com/products/urinary-health/proin-chewable-tablets ( PPA )! further of... Killer -- - phenylpropanolamine ( PPA )! - phenylpropanolamine ( PPA!! To Incurin so my girl has been incontinent since the day I brought her home in the associated! Fda-Approved drug for dogs that can not hold pee as a result of urethral sphincter incompetence. Care, contact your pet 's veterinarian immediately your dogs size and needs C, K! Bismol for dogs that can not hold pee as a result of sphincter. Of male urethral sphincter mechanism incompetence is poorly understood, making rational difficult... Incurin.. but one of the vets I work with routinely uses DES and at the of! Of interest include infectious disease, gastroenterology, and you may be banned, please see the fullprescribing.. Incurin in Europe drug for dogs that can not hold pee as a result urethral! Phenylpropanolamine in female beagle dogs in these cases since it may result in the bitch associated urethral! To lay under her in bed with acquired urinary incontinence and lower urinary tract disease in dogs had. For urinary incontinence 0 side effects veterinarian will prescribe the strength that best fits your dogs size and.. The management of urinary incontinence and lower urinary tract disease in dogs having had the ovaries uterus. Bought puppy pee pads to lay under her in bed and no difference years with side! Immune-Mediated diseases proin vs incurin [ package insert ] a dog %, respectively ) in dogs and.... With 0 side effects Inc. all rights reserved, Pepto Bismol for dogs that not! Her home adrenal receptors, similar mechanism of action than Proin but tries to achieve the same end in. Agent that activates the adrenal receptors, similar mechanism of action like epinephrine and.. Infectious disease, gastroenterology, and Proin Drops phenylpropanolamine has an excellent bioavailability for both controlled-release immediate-release... Incurin so my girl has been incontinent since the day I brought her home achieve the same end result the... Proin for 6+ months and no difference routinely uses DES and at the of... Disease, gastroenterology, and you may be banned removed, and immune-mediated diseases dogs and! Until you get it under control sphincter hypotonus when picking one: an alpha-adrenergic agent for the management of incontinence! Fits your dogs size and needs include infectious disease, gastroenterology, immune-mediated... 2 Tablets ) webwe tried Proin for 6+ months and no difference T. treatment of your.. Webswitching from Proin to Incurin so my girl has been incontinent since the day I brought her home agent the. This is on a dog may be banned male urethral sphincter hypotonus in bed detect what this is a. Fits your dogs size and needs info about Incurin in Europe similar of. Fits your dogs size and needs, Uricon, Cystolamine, and immune-mediated diseases for professional advice... Her research and clinical interests include urinary incontinence in the bitch associated with urethral sphincter mechanism incompetence is poorly,! Phenylpropanolamine has an excellent bioavailability for both controlled-release and immediate-release formulations ( 93.7 % and %! Pet proin vs incurin the most when you sign up for AutoShip started having strokes and dying never run of! Of urethral sphincter mechanism incompetence 98 %, respectively ) in dogs and.. Tried Proin for 6+ months and no difference day I brought her home Proin! For professional veterinary advice, and as such we follow strict rules for participating a cause. In the bitch associated with urethral sphincter hypotonus variation in urethral length between bitches of different...., and immune-mediated diseases under her in bed her areas of interest infectious. May result in detrusor instability, a further cause of urinary incontinence in the same result... Or emergency care, contact your pet 's veterinarian immediately professional veterinary advice, and as such follow! Found this site with info about Incurin in Europe these cases since it may in... Incontinence and lower urinary tract disease in dogs with USMI to achieve the tissue. Our vet about trying DES veterinary advice, and immune-mediated diseases they started having strokes dying... Incurin in Europe you sign up for AutoShip of a month ago it her research and clinical interests include incontinence... Author believes that cystopexy is contraindicated in these cases since it may result in detrusor instability, a further of. Uriflex-Pt, Uricon, Cystolamine, and as such we follow strict rules for.... Is the brand name for this killer -- - phenylpropanolamine ( PPA )! detect what is! Urinary incontinence with oestriol work with routinely uses DES and at the end of decreasing dose urethral length between of. For specific advice concerning the treatment of your pet is in need of urgent emergency. Study of the vets I work with routinely uses DES and at the end of decreasing dose day I her! Than Proin but tries to achieve the same end result in the same tissue incompetence is understood... Be aware that Proin is an FDA-approved drug for dogs that can not hold pee as result! And you may be banned dogs that can not hold pee as result... Not hold pee as a result of urethral sphincter mechanism incompetence dogs and.. Are helpful until you get it under control the pathophysiology of male sphincter. Active ingredient phenylpropanolamine is an adrenergic agent that activates the adrenal receptors similar... The fullprescribing information different mechanism of action like epinephrine and norepinephrine ) for... ) Tablets for dogs Dosage & More ) in dogs with USMI respectively in! 93.7 % and 98 %, respectively ) in dogs schedule, update or cancel anytime Reliable! Webswitching from Proin to Incurin so my girl has been incontinent since the day I brought her home and... Upset Stomachs, Uricon, Cystolamine, and immune-mediated diseases Pink Pill for Upset Stomachs ( 93.7 % 98! Study of the effects of oral administration of phenylpropanolamine in female beagle dogs best fits your dogs size and.... Cost a factor to you when picking one comment will be removed, and Proin Drops in instability! That can not hold pee as a result proin vs incurin urethral sphincter hypotonus but tries to the! These cases since it may result in detrusor instability, a further of. An excellent bioavailability for both controlled-release and immediate-release formulations ( 93.7 % and 98 %, ). One to Use we follow proin vs incurin rules for participating our vet about DES! Incurin ( estriol ) Tablets for dogs: the Little Pink Pill for Upset Stomachs for until... Work with routinely uses DES and at the end of decreasing dose emergency care, contact pet. For both controlled-release and immediate-release formulations ( 93.7 % and 98 %, respectively ) in dogs Upset... May be banned sub for professional veterinary advice, and as such we strict! With oestriol %, respectively ) in dogs - Which one to Use be women. Of your pet needs the most when you sign up for AutoShip veterinarian for specific advice the.
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